Testosterone cypionate, sold under the brand name Depo-Testosterone among others, is an androgen and anabolic steroid (AAS) medication primarily used in the treatment of low testosterone levels in men, including hormone therapy for transgender men. It is administered via intramuscular or subcutaneous injection, typically once every one to four weeks, depending on clinical needs.

How It Works

Testosterone cypionate is a synthetic androgen and anabolic steroid, acting as an agonist of the androgen receptor (AR) — the biological target of testosterone and dihydrotestosterone (DHT). It is converted by the body into active testosterone, producing both androgenic and anabolic effects.

Testosterone can act directly or be metabolized by 5α-reductase into DHT, or aromatized to estradiol (E2). Both testosterone and DHT bind to AR, but DHT binds more strongly, often delivering more potent androgenic effects in some tissues.

Bodybuilding Benefits

• Enhances muscle growth and recovery

• Boosts strength and physical performance

• Offers stable hormone levels due to its long-acting ester

• Favored for longer cycles and steady results

Side Effects

Like other forms of testosterone, side effects can include:

• Acne

• Increased hair growth

• Voice deepening

• Increased sexual desire

• Lower emotional threshold for aggression

History and Usage

Testosterone cypionate was introduced for medical use in 1951. It is especially popular in the United States and remains one of the most commonly used testosterone esters alongside enanthate, propionate, and undecanoate.

While widely used for androgen replacement therapy, it is also known in the fitness and bodybuilding community for enhancing physique and performance. However, its non-medical use is regulated and considered illicit in many countries due to its classification as a controlled substance.